Allometric is dedicated to helping early-stage innovators translate discoveries into clinical and commercial realities

Andrew Hegle, PhD, PMP

I am a scientific business leader with deep experience guiding novel therapeutics from early research into clinical development. Trained in neuroscience at the University of Michigan, over the past decade I’ve directed multi-disciplinary programs across North America, Europe, and Asia, served as Chief Science Officer and board member, and overseen the scientific, operational, and regulatory elements required to bring a therapeutic to first-in-human studies.

My work has included building teams from scratch, coordinating global CROs and vendors, preparing IND/CTA submissions, building quality systems, guiding GMP manufacturing programs, and establishing GCP-compliant eTMF platforms. At my most recent startup, Entheon Biomedical, I designed and led a phase 1 clinical trial for a novel addiction therapy, an effort completed ahead of schedule and ultimately acquired by a larger company. I’ve also had the pleasure to serve as a university instructor, mentoring early-career scientists in pharmacology and therapeutics at the University of British Columbia.

Across all these roles, I’ve brought a consistent approach: taking the time to understand how all the moving parts fit together, bringing order and structure to ambiguity, and collaborating closely with teams to create an environment where people feel supported and confident in their decisions.

I am passionate about helping teams that are driven by scientific curiosity, integrity, and the desire to make a meaningful impact. Whether advising founders, supporting program teams, or stepping in as fractional leadership, my goal is to help promising science advance smoothly, responsibly, and confidently toward the clinic and beyond. If you’re building something important and need an experienced partner to help you move forward, I’d love to help.

Andrew was instrumental in helping us to secure funding, communicating the value of our science to investors, and overseeing all parts of our clinical development.

- Startup CEO

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